First things first, and that cooling off a Texans’ team that has won seven straight games. Of course, Harbaugh and quarterback Justin Herbert won’t soon forget last year’s playoff disaster at Houston in which the latter was picked off four times —one of those returned for a touchdown—in an embarrassing 32-12 setback.

The Chargers' season came to a screeching stop in Houston last season. L.A. was riding a three-game winning streak but was overwhelmed in a lopsided, wild-card loss that marked the worst game of Herbert's career.

The Chargers are dealing with a laundry list of offensive line injuries heading into a game against the Texans.

The Chargers offense face a tough test against the Houston Texans and their vaunted defense. The Texans defense has a few areas that the Chargers will attack.

Justin Herbert's dual-threat dominance, Hampton's punishing runs, and Johnston's game-breaking catches present a critical challenge for Houston's defense.

The Houston Texans and Los Angeles Chargers are practically mirror images this season, teams with elite defenses and erratic offenses still trying to stay alive in their respective AFC divisional races.

There was no shortage of action during Sunday’s matchup between the Dallas Cowboys and the Los Angeles Chargers. In the end, it was the Chargers who secured a 34-17 road victory at AT&T Stadium, officially shutting down the Cowboys’ playoff chances.

Herbert will have his hands full against the best pass rush duo in football.

Preview the NFL week 17 matchup between the Los Angeles Chargers and Texans, including betting odds, tips, trends, and game information.