Meme | Funny | Culture on Instagram: "The “Not you, bruh” meme comes from a short viral clip where someone is trying to point out a person doing something wrong or embarrassing, and another person quickly intervenes with the phrase “Not you, bruh,” signaling disbelief or frustration. The delivery is deadpan but perfectly timed, which made it hilarious to viewers and perfect for reaction videos and comment threads online. What made the meme stick was how universally applicable the phrase became.